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Afix (Cefixime) is a broad spectrum 3rd generation cephalosporin antibiotic for oral administration. It is a bactericidal antibiotic and is stable to hydrolysis by many beta-lactamases. Cefixime kills bacteria by interfering the synthesis of the bacterial cell wall. It is highly active againstincluding beta-lactamase producers, most of the , beta-haemolytic Streptococci (Group A & B) and .
It is more active than other oral cephalosporins againstand . It is also active against . 40-50% of an oral dose is absorbed from gastro-intestinal tract, whether taken with meals or not. The plasma half-life is usually about 3 to 4 hours and may be prolonged when there is renal impairment. About 65% is bound to plasma protein. Cefixime is mainly excreted unchanged in bile and urine.