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Cefepime is a bactericidal agent that acts by inhibition of bacterial wall synthesis. It has a broad spectrum of activity against a wide range of gram-positive and gram-negative bacteria including most strains resistant to aminoglycosides or third-generation cephalosporins such as ceftazidime. Cefepime is highly resistant to hydrolysis by most beta-lactamases and exhibits rapid penetration into gram-negative bacterial cells. In studies, cefepime bound with highest affinity to penicillin binding protein (PBP) 3 followed by PBP 2, then PBPs 1a and 1b.