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Erythropoietin concentrated solution (rDNA)
Erythropoietin is a glycoprotein hormone produced primarily by the kidney in response to hypoxia and is the key regulator of red blood cell (RBC) production. Erythropoietin is involved in all phases of erythroid development, and has its principal effect at the level of erythroid precursors. After erythropoietin binds to its cell surface receptor, it activates signal transduction pathways that interfere with apoptosis and stimulates erythroid cell proliferation. Recombinant human erythropoietion is structurally and functionally identical to the endogenous erythropoietin and is manufactured by recombinant DNA technology. Patients with chronic renal failure cannot produce sufficient amount of endogenous erythropoietin that leads to anemia. In that case, exogenous erythropoietin (rch) stimulates erythropoiesis to recover the signs and symptoms of anemia.