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Losartan Potassium & Hydrochlorothiazide
Losartan Potassium is the first orally active angiotensin-II receptor (type-AT1) antagonist. Osartan and its principal active metabolite block the vasoconstrictor and aldosterone secreting effects of angiotensin-II to the AT1 receptor.
Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly by increasing sodium excreation. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume with consequent increase in plasma renin activity, aldosterone secretion, urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so co-administration of Losartan tends to reverse the potassium loss associated with Hydrochlorothiazide.