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Cefpodoxime Proxetil is an orally administered prodrug that is de-esterified in the intestinal wall to release Cefpodoxime, a third generation cephalosporin. Cefpodoxime is a broad spectrum antibiotic and is active against beta-lactamase producing staphylococci. Cefpodoxime binds with high affinity to penicillin-binding proteins in the bacterial cell wall, thus interfering in peptidoglycan synthesis that provides the cell wall with mechanical stability. Cefpodoxime inhibits the transpeptidase enzyme that performs the final stage in the synthesis of peptidoglycan. As a result, the bacterial cell wall is weakened, and the cell swells and then ruptures.