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Product Code : 159
- Terbinafine hydrochloride is a synthetic allylamine antifungal, which is fungicidal against dermatophytes, mold fungi and some yeasts.
- Terbinafine interferes with fungal ergosterol biosynthesis by inhibiting squalene epoxidase in the cell membrane. This leads to a deficiency of ergosterol and an intracellular accumulation of squalene, thus disrupting fungal membrane function and cell wall synthesis resulting in fungal cell death.
- Terbinafine does not inhibit cytochrome P450 activity and is weakly bound to hepatic cytochrome P450 enzymes. Terbinafine is distributed into the stratum corneum of the skin, the nail plate and hair in higher concentration than found in plasma.