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Fenofibrate is a fibric acid derivative. Fenofibrate is rapidly hydrolysed after oral ingestion into its pharmacologically active form fenofibric acid. Fenofibrate reduces total cholesterol, LDL cholesterol, apoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, Fenofibrate increases high density lipoprotein (HDL) and apo Al and apo All. The effects of Fenofibrats have seen in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor a (PPARa). Fenofibrate also reduces serum uric acid levels in hyperuremic patients by increasing the urinary excretion of uric acid.